Results
| PMID | 21269613 |
| Gene Name | ESR1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 41 |
| Population details | 41 (18 patients with stage IV endometriosis, ) |
| Sex | Female |
| Associated genes | ER-alpha, ER-beta, PR-A, PR-B |
| Other associated phenotypes |
Endometriosis, Ovarian dysfunction, Tubal infertility |
|
Fertil Steril. 2011 Mar 1;95(3):889-94. doi: 10.1016/j.fertnstert.2010.12.026. Karita, Masako| Yamashita, Yoshiki| Hayashi, Atsushi| Yoshida, Yoko| Hayashi, Mika| Yamamoto, Hikaru| Tanabe, Akiko| Terai, Yoshito| Ohmichi, Masahide Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka, Japan. OBJECTIVE: To evaluate how endometriosis affects the expression of estrogen and progesterone receptors mRNA in granulosa cells. DESIGN: Prospective study. SETTING: IVF-ET program at Osaka Medical College. PATIENT(S): Eighteen patients with revised American Fertility Society stage IV endometriosis and 23 patients with tubal infertility without endometriosis. INTERVENTION(S): Granulosa cells obtained from patients with endometriosis were examined for estrogen (ER-beta, ER-alpha) and progesterone (PR-A, PR-B) receptor mRNA expression ratio against GAPDH. MAIN OUTCOME MEASURE(S): Hormonal environment and clinical outcome were investigated. Expression of ER and PR mRNA were evaluated by StepOne real-time polymerase chain reaction (PCR) analysis. RESULT(S): Total hMG/FSH levels were statistically higher in patients with endometriosis; however, high-quality embryo rates and pregnancy rates were lower in patients with endometriosis than in patients with tubal infertility. Expression of PR-A and ER-alpha in patients with endometriosis was statistically higher than in patients with tubal infertility. The expression of PRs and ERs in patients with tubal infertility showed a positive correlation; however, it was not identified in the endometriosis group. CONCLUSION(S): The higher PR-A and ER-alpha gene expression in granulosa cells in patients with endometriosis, compared with patients with tubal infertility, might be a leading cause of ovarian dysfunction due to endometriosis. Mesh Terms: Adult| Endometriosis/*genetics/pathology| Estrogen Receptor alpha/*genetics| Estrogen Receptor beta/*genetics| Female| Gene Expression Regulation/physiology| Granulosa Cells/*physiology| Humans| Infertility, Female/genetics/pathology| Pregnancy| |
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